AICAR (powder) Details:
CAS ID: 2627-69-2
Synonyms: Acadesine; Aminoimidazole carboxamide ribonucleotide;
Molecular Formula: C9H15N4O8P
Molecular Weight: 338.211162
Appearance: White Powder
Melting point: 213-214 °C
Storage: Before reconstitution (lyophilized / freeze dried powder):
Can be stored in the refrigerator (2°C to 8°C = 35°F to 47°F) for
Can be stored at room Temperature (up to 37°C = 99°F) for 90 days.
After reconstitution (liquid):
Can be stored in the refrigerator (2°C to 8°C = 35°F to 47°F) for 5
Transportion time at room temperature has not effect on product
Solubility: Soluble in DMSO (15 mg/ml); or water (15 mg/ml).
Aicar is a peptide, which is an intermediate within the generation
of inosine monophosphate and directly related to metabolic
regulation. The most important mechanism that Aicar is known for is
its ability to block enzymes both in intracellular and
extracellular levels, which, in turn, allows for an accelerated
stimulation of glucose uptake and increase protein kinases in
skeletal muscle tissue. These two functions allow for more energy
conversion, which helps burn fat and also sustain output in
activity. This is what scientists and athletes/bodybuilders are
Aicar's principal mechanism of action is activation of AMPK
(AMP-activated protein kinase.) Activating AMPK, therefore, causes
the same cellular machinery (so to speak) to be turned on as if the
cell were energy deprived, for example from intensive exercise, or
from low caloric intake.
Aicar, at sufficient and quite substantial concentration, is
effective at activating AMPK and inducing a cellular state as if
exercise had been performed, or energy stores were low and fat
therefore needed to be burned.
Aicar uses metabolic pathways to block certain enzymes, which
allows for AMP-activated protein kinase. This can be explained to
the layperson like this: once you take a substantial amount of
AICAR, it tricks your body at a cellular level in to thinking that
exercise has just been preformed. Since the body thinks it has just
done a considerable amount of exercise, the energy cycle at the
cellular level starts converting fuel sources, like fatty acids, to
output the energy that was thought to have been spent during
exercise. This can have a direct effect on the level of endurance
activity and the sustainability of that activity. Insulin
sensitivity is also noted to be one action that Aicar produces, as
the body will think it just went through a series of exercises.
Interestingly, in animal studies with obese mice, Aicar showed all
of the peptides benefits for obese diet induced mice, yet the
healthy lean mice did not reap any of the benefits of insulin
sensitivity or increase in glucose uptake. That being said, the
application in bodybuilding does not seem very suitable, as these
mechanisms are targeted for the out-of-shape and over-weight.
Interestingly, Aicar has been shown to protect against ischemic
injury. This type of injury is directly related to the restriction
of blood to tissues, which can cause insufficient amounts of oxygen
and glucose needed to keep the tissue alive. This can lead to
thrombosis, embolisms, and vasoconstriction. Aicar can be used as a
stabilizing peptide for ischemic episodes, and it can allow for
proper blood flow to the myocardium (heart). This function is very
interesting, as Aicar could be fundamentally used to treat the
heart muscle in the aftermath of a heart attack. This might reduce
the possibility for ischemic injuries. Abnormal growths of heart
tissues and heart valve function have also been altered in animal
studies that used the peptide Aicar, which is a downside.
How Does AICAR Work?
AICAR will trigger AMP activated protein kinase (AMPK), leading to
glucose uptake by cells of skeletal muscle. In fact, The Howard
Hughes Medical Center and Salk Institute ran a series of
experiments with AICAR in the 2000’s. In these studies they found
out that mice that were given AICAR could run 44% further, even
without training for it. Consequently, once endurance athletes got
word of this amazing compound, AICAR was being used without any
regulation or fear of testing until 2011.
AICAR works by stimulating the glucose uptake and increasing the
activity of p38 mitogen-activated protein kinases a and b in
skeletal muscle tissue. Additionally, its reduction of reactive
oxygen compounds within cells suppresses apoptosis; that is, the
process of programmed cellular death that may occur in animal test
subjects. In other words, it increases the type of fuel responsible
for the maintenance and regulation of skeletal muscle tissue while
prolonging the life of cells.
The functionality of AICAR was pinpointed during extensive research
conducted by the Salk Institute in 2008, when it conducted a
battery of studies on laboratory rats. According to this particular
research, it was determined that the mice that were given AICAR
exhibited a significant improvement concerning endurance-type
exercise. While the mechanics of this particular improvement were
not isolated and specified, it was theorized that it was due to
AICAR's facility for converting fast-twitch muscle fibers to
slow-twitch muscle fibers. This conversion in turn allowed for a
much higher rate of energy efficiency amongst the lab rats.
Additionally, the scientific tests noted that the conversion also
allowed for a more efficient fat burning process amongst the animal
AICAR STACKING WITH GW-501516
Both AICAR and GW 501516 (cardarine) are on WADA’s banned
substances list, and if used together they make a potent endurance
stack. One of the differences between the two is that GW501516 is a
PPAR-delta agonist, while AICAR is a PPAR-delta AMPK axis agonist.
In terms of doping, GW is easily detectable for up to 40 days in
urine tests, as it is not a naturally occuring substance in the
body. Meanwhile, AICAR is a naturally occuring substance in the
body, so this makes it more difficult to test for. To combat this,
a baseline value was established, which determines if someone is
using AICAR to dope with. Nevertheless, it has still been proven to
be harder to catch cheaters using AICAR than GW. For instance, a
Spanish team cycling doctor was caught with AICAR in his luggage,
so we know cyclists are using it - they just aren’t getting caught.
1)Location & Working Hours
We are an International source locate in China.
I will answer emails from Monday to Saturday, 8:30 am to 18:00 pm
2)How long does it takes to get back a response from you?
You should receive a response in less than 24 hours.
3)How do I make an order?
When you choosed the products, please email me, and I will quote
for you, if you are satisfied with it, then pay for it, the parcle
will be sent for you as soon as possible.
4)How to track my order?
After I ship your order and have the tracking number, you will
receive an email notification. All tracking numbers I provide can
be tracked at http://www.17track.net/en. Or you can ask me for
helping you track it too.
5)How long does the whole process take, from making an order till
receiving the package?
The package will be prepared within 1 working day after payment
received and be sent out within 72 hours.
The delivery time depends on the shipping situation and customs.
The shipping time will not more than 15 working days at most.
6)How about the shipping cost?
The shipping cost is for the whole order. No matter how many
different items and quantity in one orders. The shipping cost will
be charged only once.
7)Is there a minimum order?
For raw powder: MOQ is 10g
For oil liquid: MOQ is 50ml
For peptide vial: MOQ is 10 vials
To U.S. We reship for free twice if your package gets seized.
To other countries we reship for free once if your package gets
If you choose not to reship or the resent package failed to go
through again, no refund will be made.
We accept Bank Transfer(T/T ), Western Union, Moneygram, Bitcoin.
*** The Bitboin is a little special for us, our Bitcoin account is
always changing, once I gave you the account number, please pay for
it at once.
Our company has a 2 reship policy all foreign countries in case of
a seizure. If you fail to receive your reship(s), no refunds will
**We are not responsible if you throw away your products because
you cannot find them in our disguised package. If you cannot find
your products please email me and I will tell you where to find
Product list :
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|1||Test Enanthate||CAS: 315-37-7|
|2||Test Base||CAS: 58-22-0|
|3||Test Acetate||CAS: 1045-69-8|
|4||Test Propionate||CAS: 57-85-2|
|6||1-Test Cyp||CAS: 65-06-5|
|7||Test Phenylpropionate||CAS: 1255-49-8|
|8||Test Isocaproate||CAS: 15262-86-9|
|9||Test decanoate||CAS: 5721-91-5|
|10||Test Sustanon 250/100||/|
|11||Test Undecanoate||CAS: 5949-44-0|
|16||Oral Turinabol||CAS: 2446-23-3|
|23||Nandro Decanoate (DECA)||CAS: 360-70-3|
|24||Nandro Cypionate||CAS: 601-63-8|
|25||Nandro Undecanoate||CAS: 862-89-5|
|26||Nandro Phenylpropionate||CAS: 62-90-8|
|27||Tren Acetate||CAS: 10161-34-9|
|28||Tren Enanthate||CAS: 10161-33-8|
|30||Tren Hexahydro Carbonate||CAS: 23454-33-3|
|31||Trestolone Acetate||CAS: 436144-67-1|
|35||Bolden Propionate||CAS: 63321-10-8|
|36||Bolden Acetate||CAS: 10161-34-9|
|37||Bolden Cypionate||CAS: 106505-90-2|
|38||Bolden Undecylenate||CAS: 13103-34-9|
|40||Drostan Propionate||CAS: 521-12-0|
|41||Drostan Enanthate||CAS: 472-61-145|
|42||Superdrol Powder||CAS: 3381-88-2|
|DH EA SERIES|
|46||7-keto DH EA||CAS: 566-19-8|
|47||Methenolone Enanthate||CAS: 303-42-4|
|48||Methenolone Acetate||CAS: 434-05-9|
|54||Tamoxifen Citrate (Nolvadex)||CAS: 54965-24-1|
|55||Clomiphene citrate (clomid)||CAS: 50-41-9|
|56||Toremifene citrate||CAS: 89778-27-8|
|EPINEPHRINE & THYROXINE|
|61||T4 / L-Thyroxine||CAS: 25416-65-3|
|62||L-Epinephrine HCl||CAS: 55-31-2|
|63||L-Noradrenaline Bitartrate||CAS: 108341-18-0|
|65||Phenylephrine hydrochloride||CAS: 61-76-7|
|66||Epinephrine bitartrate||CAS: 51-42-3|
|77||Acetildenafil (Hongdenafil)||CAS: 831217-01-7|
|79||Dapoxetine hydrochloride||CAS: 129938-20-1|
|80||Dapoxetine HCl||CAS: 119356-77-3|
|82||Finasteride (Proscar)||CAS: 98319-26-7|
|83||Yohimbine HCl||CAS: 65-19-0|
|86||Megestrol Acetate||CAS: 595-33-5|
|97||CJC-1295 with DAC||CAS: 863288-34-0|
|98||CJC-1295 without DAC||CAS: 863288-34-0|
|109||Pentadecapeptide BPC||CAS: 137525-51-0|
|110||HG hFragment 176-191||CAS: 158861-67-7|
|116||IG F-1Lr3||CAS: 946870-92-4|
|Local Anesthetic Powder|
|131||Benzocaine HCL||CAS: 23239-88-5|
|132||Bupivacaine HCL||CAS: 14252-80-3|
|133||Levobupivacaine HCL||CAS: 27262-48-2|
|135||Lidocaine HCL||CAS: 73-78-9|
|136||Pramoxine HCL||CAS: 637-58-1|
|139||Procaine HCL||CAS: 51-05-8|
|140||Propitocaine HCL||CAS: 1786-81-8|
|141||Ropivacaine HCL||CAS: 132112-35-7|